Brain neuromarkers predict self- and other-related mentalizing across adult, clinical, and developmental samples
Açil, D., Andrews-Hanna, J. R., López-Solà, M., van Buuren, M., Krabbendam, L., Zhang, L., van der Meer, L., Fuentes-Claramonte, P., Pomarol-Clotet, E., Salvador, R., Debbané, M., Vrticka, P., Vuilleumier, P., Sbarra, D. A., Coppola, A. M., Tusche, A., White, L. O., Wager, T. D., & Koban, L.
Abstract
Human social interactions rely on the ability to reflect on one's own and others' internal states and traits-a psychological process known as mentalizing. Impaired or altered self- and other-related mentalizing is a hallmark of multiple psychiatric and neurodevelopmental conditions. Yet, replicable and easily testable brain markers of mentalizing have so far been lacking. Here, we apply an interpretable machine learning approach to multiple datasets (total
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Citation: Açil, D., Andrews-Hanna, J. R., López-Solà, M., van Buuren, M., Krabbendam, L., Zhang, L., van der Meer, L., Fuentes-Claramonte, P., Pomarol-Clotet, E., Salvador, R., Debbané, M., Vrticka, P., Vuilleumier, P., Sbarra, D. A., Coppola, A. M., Tusche, A., White, L. O., Wager, T. D., & Koban, L. (2026). Brain neuromarkers predict self- and other-related mentalizing across adult, clinical, and developmental samples. Nature Communications, 17, 7229.